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KMID : 0604520090350040317
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Journal of the Society of Cosmetic Scientists of Korea
2009 Volume.35 No. 4 p.317 ~ p.323
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Anti-wrinkle Activity of Lindera obtusiloba Extract
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Park Keum-Ju
Park Seung-Hee
Kim Jae-Ki
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Abstract
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Chronic exposure of solar ultraviolet (UV) light to human skin results in photoaging with wrinkle formation. This study was performed to investigate anti-wrinkle effects of Lindera obtusiloba extract (LO) on UVB-induced wrinkle formation. We first measured cell proliferation and type I pN collagen synthesis activities in normal human dermal fibroblasts. Cell proliferation and type I pN collagen synthesis were increased by 33.8 % and 91.8 %, respectively, compared with no treatment control. SKH-1 hairless mice were topically applied 5 % LO solution for 10 weeks with UVB irradiation three times a week. After 10 weeks, a visual assessment and replica assay were performed on each mouse. According to visual assessment of close-up photos and skin replica, application of 5 % LO solution inhibited UV-induced wrinkle formation in mouse skin as compared to the vehicle-applied control mice. These results indicated that LO could protect skin wrinkle formation caused by chronic photo-irradiation in hairless mice.
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KEYWORD
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Lindera obtus, loba extract, anti-wrinkle, ultra violet, free radical
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